We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Ausonius has become a more accessible writer since the appearance of Professor Green's acclaimed commentary on him in 1991, which among other things stimulated discussion of his text and the textual tradition. This newly revised text takes advantage of recent criticism, both conservative and conjectural, and re-examines the difficulties inherent in the long held view that extant manuscripts derive independently from separate authorial editions. The opportunity has been taken to reassess earlier decisions on various problematic passages and to introduce several (...) new emendations, either in the text or in the apparatus criticus. There is a newly written introduction, in English, the apparatus criticus has been pruned, the concordances expanded, and the bibliography updated. The works in this new Oxford Classical Texts version of the text follow the same order as was established in Professor Green's previous edition of 1991. (shrink)

In this paper I challenge the traditional reading of Daoism as naturalism and the interpretation of wu wei as “acting naturally.” I argue that such an interpretation is problematic and unhelpful to the would-be Daoist environmental ethicist. I then lay the groundwork for a philosophically viable environmental ethic by elucidating the pragmatic aspects of Daoist thought. While Daoism so interpreted is no panacea for all of our environmental ills, it does provide a methodology that may prove effective in alleviating some (...) of our discomfort. (shrink)

RésuméL'objet du présent article est de dégager la signification philosophique des différents théoriémes de métamathématique relatifs à la puissance des formalisations. Ces théorèmes représentent la partie de l'épistémologie qui peut être exposée dans la forme technique de la science elle‐même et rassemblant les éléments d'une réflexion autocritique de la pensée mathématique sur elle‐même. Au‐delà, ils invitent à comprendre l'acte de la pensée mathématique comme déploiement d'un projet pensant supposant à la fois une initiative volontaire de la pensée, un champ intuitif (...) absolument indéfini et une exigence logique régulatrice, et amènent la philosophie de la science à se demander si, telles qu'ellcs sont, les mathématiques sont l'unique forme de synthèse rigoureuse possible entre ces trois moments de la pensée. (shrink)

(No abstract is available for this citation).

Type theory is a fast-evolving field at the crossroads of logic, computer science and mathematics. This gentle step-by-step introduction is ideal for graduate students and researchers who need to understand the ins and outs of the mathematical machinery, the role of logical rules therein, the essential contribution of definitions and the decisive nature of well-structured proofs. The authors begin with untyped lambda calculus and proceed to several fundamental type systems culminating in the well-known and powerful Calculus of Constructions. The book (...) also covers the essence of proof checking and proof development, and the use of dependent type theory to formalize mathematics. The only prerequisites are a good knowledge of undergraduate algebra and analysis. Carefully chosen examples illustrate the theory throughout. Each chapter ends with a summary of the content, some historical context, suggestions for further reading and a selection of exercises to help readers familiarize themselves with the material. (shrink)

It may seem faintly absurd to claim or imply that a Vergilian cento has suffered unjustified neglect from scholars. These works—of which there are sixteen, covering a period of over three centuries within Late Antiquity—are usually treated at best with amused tolerance, and at worst with angry disdain. Though always ingenious, sometimes funny, and occasionally informative about the reception of Vergil, they are seldom admired. Even among Italian scholars, some of whom have paid much attention to centos, a recession has (...) set in since the annus mirabilis of 1981, which saw two editions of the Medea of Hosidius Geta. Proba has, deservedly, attracted more attention than most; her aims and methods as a Christian poetess were carefully and illuminatingly studied twenty years ago by Reinhard Herzog, and her interest as a female Roman aristocrat has brought her further attention, especially in recent years. The main aim of the present article is to suggest a particular context and a serious purpose for her cento. A postscript will show that it went on to enjoy considerable popularity until the end of the century, and an introductory section will discuss its date, but very briefly, since Matthews has convincingly said most of what needs to be said about a recent attempt to redate it. Proba's preface, much of it not in cento form, calls for detailed treatment from various angles—textual, literary, historical—and will be explored in a separate article. (shrink)

What we perceive is the product of an intrinsic process and not part of external physical reality. This notion is consistent with the philosophical position of transcendental idealism but also agrees with physiological findings on the thalamocortical system. -Frequency rhythms of discharge activity from thalamic and cortical neurons are facilitated by cholinergic arousal and resonate in thalamocortical networks, thereby transiently forming assemblies of coherent oscillations under constraints of sensory input and prefrontal attentional mechanisms. Perception and conscious experience may be based (...) on such assemblies and sensory input to thalamic nuclei plays merely a constraining role in their formation. In schizophrenia, the ability of sensory input to modulate self-organisation of thalamocortical activity may be generally reduced. If during arousal thalamocortical self-organisation is underconstrained by sensory input, then attentional mechanisms alone may determine the content of perception and hallucinations may arise. (shrink)

It is proposed that happiness be classified as a psychiatric disorder and be included in future editions of the major diagnostic manuals under the new name: major affective disorder, pleasant type. In a review of the relevant literature it is shown that happiness is statistically abnormal, consists of a discrete cluster of symptoms, is associated with a range of cognitive abnormalities, and probably reflects the abnormal functioning of the central nervous system. One possible objection to this proposal remains--that happiness is (...) not negatively valued. However, this objection is dismissed as scientifically irrelevant. (shrink)

The import of this long and careful study is primarily negative: the author attempts to show that the various theories which contemporary analysts have held against the a priori are not tenable; he leaves us not with still another proposal but with the conviction that this philosophical ground is still fertile.--R. P.

The disappearance of the imperial biographies written by Marius Maximus is one of the more frustrating losses of Latin literature, for various reasons: the well-known testimony of Ammianus, the interest of Marius Maximus' attested contribution to the Historia Augusta, his importance, much in dispute, to the writer of that work, the lack of information on much of the period he covered, and, not least, the fascinating role assigned to him by modern scholars, remodelling a previous duality of sources, of bad (...) biographer in contrast to the good Ignotus. It has recently become common practice for the evidence of Ausonius' Caesares to be used in the search for this biographer. The suggestion goes back to a dissertation of F. della Corte in 1956/7, and was taken up in his edition of Ausonius' works by Pastorino, and discussed in the following year by Cazzaniga who, though uncertain about the dependence of Ausonius on Marius Maximus, does misleadingly assert ‘e certo che l'ultima epigramma tocca Elagabalo, che chiude la silloge’. More recently, della Corte has returned to the question and sketched a possible model for the growth of the whole extant collection of Ausonius' Caesares, on the basis of the manuscript tradition. The same volume contains a contribution to the question by S. d'Elia and includes, by a felicitous piece of editing, an extended footnote in which d'Elia is able to comment on the relevant part of della Corte's paper. Meanwhile, outside Italy, there have been parallel and independent developments. (shrink)

The present paper is an attempt to develop late Professor K. Satchidananda Murty’s quest to articulate Immanent and Transcendent in his philosophical journey from Upanishads to German idealism and Marxism. It is proposed to be achieved by explicating Murty’s understanding of the views of Kant, Hegel, Feuerbach, and Marx on human condition and its transcendence or emancipation. For this purpose, I will discuss consciousness as the ultimate reality being transcendent and immanent in Vedanta as well as in German idealism. The (...) ambition and challenge of the present article is to pursue Murty’s cross-cultural perspective to the extent that the ideas of thinkers of very different traditions, especially culturally and intellectually distinct traditions, are contested on the fullness of thought concerning immanent and transcendent as is evident in comparing Sankara, Kant, and Hegel on consciousness in relation to Buddha and Marx on suffering and alienation. Whereas Murty refers to them, from cross-cultural perspective, with limited end to substantiate his position on the “realm between” derived from Upanishads and Vedanta infused with Buddhism, I wish to present, from the same perspective, some clarifications, annotations, and summations from German idealism and Marxism, which may be useful for expanding Murty’s preliminary acquaintance with them. I wish to argue that though there is antithetical nature of these perspectives, yet the distinctions between immanent and transcendent have been one of the fundamental conceptual linkages under different cultural background. (shrink)